B7
Prof. Dr. Mulert
Neurochemische und neurophysiologische Mechanismen der Interaktion von Belohnungsverarbeitung mit Bottom-up und Top-down Netzwerken: die Rolle von Dopamin und E/I – Balance
Projekt B7 untersucht die Interaktion von „bottom-up“ und „top-down“ gesteuerter visueller Aufmerksamkeit mit der Verarbeitung von Belohnung bei gesunden Personen und Patienten mit Schizophrenie. Insbesondere konzentriert sich das Projekt B7 auf die neurophysiologischen und neurochemischen Mechanismen dieser Interaktion. Wir werden neuropharmakologische Modulation am Dopamin-Rezeptor zusammen mit trial-by-trial Kopplung von EEG-fMRI verwenden, Mehr-Kanal tACS und Modellierung des elektrischen Feldes, um die kausale Rolle von neuronalen Oszillationen bei diesem Prozess zu klären und MR-Spektroskopie, um den Zusammenhang zwischen Glutamat-Konzentrationen im visuellen Cortex und im ACC mit visuellen Auswahlprozessen zu charakterisieren.
Neue Projektrelevante Veröffentlichungen
Curic, S., Haaf, M., Zokai, D., Korkutan, T., Steinmann, S., Rauh, J., Mulert, C., Leicht, G. (2025). Effects of Glycine on Mismatch Negativity and Underlying Theta-Band Signature in the Keta-mine Model of Schizophrenia in Healthy Men. Schizophrenia Bulletin (in press)
Debnath, R., Elyamany, O., Iffland, J. R., Rauh, J., Siebert, M., Andraes, E., ... & Mulert, C. (2025). Theta transcranial alternating current stimulation over the prefrontal cortex enhances theta power and working memory performance. Frontiers in psychiatry, 15, 1493675. find paper
Elyamany, O., Iffland, J., Bak, J., Classen, C., Nolte, G., Schneider, T. R., ... & Mulert, C (2025). Predictive role of endogenous phase lags between target brain regions in dual-site transcranial alternating current stimulation. Brain Stimulation, 18(3), 780-793. find paper
Elyamany, O., Iffland, J., Lockhofen, D., Steinmann, S., Leicht, G., & Mulert, C. (2024). Top-down modulation of dichotic listening affects interhemispheric connectivity: an electroencephalography study. Frontiers in neuroscience, 18,1424746. find paper
Haaf, M., Curic, S., Rauh, J., Steinmann, S., Mulert, C., & Leicht, G. (2023). Opposite modulation of the NMDA receptor by glycine and S-ketamine and the effects on resting state EEG gamma activity: new insights into the glutamate hypothesis of schizophrenia. International Journal of Molecular Sciences, 24(3), 1913. find paper
Haaf, M., Polomac, N., Starcevic, A., Lack, M., Kellner, S., Dohrmann, A. L., Fuger, U., Steinmann, S., Rauh, J., Nolte, G., Mulert, C., & Leicht, G. (2024). Frontal theta oscillations during emotion regulation in people with borderline personality disorder. BJPsych Open, 10 (2), e58. find paper
Langhein, M., Lyall, A. E., Steinmann, S., Seitz-Holland, J., Nägele, F. L., Cetin-Karayumak, S., ... & Mulert, C. (2023). The decoupling of structural and functional connectivity of auditory networks in individuals at clinical high-risk for psychosis. The World Journal of Biological Psychiatry, 24(5), 387-399. find paper
Langhein, M., Seitz-Holland, J., Lyall, A. E., Pasternak, O., Chunga, N., Cetin-Karayumak, S., Ku-bicki, A., Mulert, C., Espinoza, R. T., Narr, K. L., & Kubicki, M. (2022). Association between peripheral inflammation and free-water imaging in Major Depressive Disorder before and after ketamine treatment–A pilot study. Journal of affective disorders, 314, 78-85. find paper
Lockhofen, D. E. L., Hübner, N., Debnath, R., Rumpf, K. P., Sander, M., Wolff, M., ... & Mulert, C (2025). Glutamatergic mechanisms in early salience processing. Frontiers in Pharmacology, 16, 1601797 find paper
Ältere projektrelevante Veröffentlichungen
Andreou, C., Frielinghaus, H., Rauh, J., Mußmann, M., S. Vauth, S., Braun, P., Leicht, G. and Mulert, C. (2017). Theta and high-beta networks for feedback processing: a simultaneous EEG & fMRI study in healthy male subjects. Translational Psychiatry, 7(1), e1016.
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Andreou, C., Steinmann, S., Kolbeck, K., Rauh, J., Leicht, G., Moritz, S., Mulert, C. (2018). The role of effective connectivity between the task-positive and task-negative network for evidence gathering [Evidence gathering and connectivity]. Neuroimage, 173, 49-56.
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Curic, S., Leicht, G., Thiebes S., Andreou C., Polomac, N., Eichler, I.C., Eichler, L., Zöllner, C., Gallinat, J., Steinmann, S., Mulert, C. (2019). Reduced auditory evoked gamma-band response and schizophrenia-like clinical symptoms under subanesthetic ketamine. Neuropsychopharmacology, 44(7), 1239-1246.
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Elyamany, O., Leicht, G., Herrmann, C. S., & Mulert, C. (2020). Transcranial alternating current stimulation (tACS): from basic mechanisms towards first applications in psychiatry. European Archives of Psychiatry and Clinical Neuroscience, 1-22.
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Haaf, M., Curic, S., Steinmann, S., Rauh, J., Leicht, G., & Mulert, C. (2021). Glycine attenuates impairments of stimulus-evoked gamma oscillation in the ketamine model of schizophrenia. bioRxiv.
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Kornmayer, L., Leicht, C. and Mulert, C. (2015). Increased gamma oscillations evoked by physically salient distracters are associated with schizotypy. Brain Topography, 28(1), 153-161.
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Kornmayer, L., Leicht, G. and Mulert, C. (2018). Attentional capture by physically salient stimuli in the gamma frequency is associated with schizophrenia symptoms. The World Journal of Biological Psychiatry, 19(sup2), S52-S62.
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Leicht, G., Andreou, C., Nafe, T., Nägele, F., Rauh, J., Curic, S., Schauer, P., Schöttle, D., Steinmann, S., Mulert, C. (2020). Alterations of oscillatory neuronal activity during reward processing in schizophrenia. Journal of Psychiatric Research, 129, 80-87.
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Leicht, G., Vauth, S. Polomac, N., C. Andreou, C., Rauh, J., Mussmann, M., Karow, A., and Mulert, C. (2016). EEG-Informed fMRI Reveals a Disturbed Gamma-Band-Specific Network in Subjects at High Risk for Psychosis. Schizophrenia Bulletin, 42(1), 239-249.
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Lockhofen, D. E. L., Hübner, N., Hemdan, F., Sammer, G., Henare, D., Schubö, A., & Mulert, C (2021). Differing Time Courses of Reward-Related Attentional Processing: An EEG Source-Space Analysis. Brain Topography, 34(3), 283-296.
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Meier, J., Nolte, G., Schneider, T.R., Engel, A.K., Leicht, G., Mulert C. (2019). Intrinsic 40Hz-phase asymmetries predict tACS effects during conscious auditory perception. Plos One, 14(4), e0213996.
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Thiebes, S., Steinmann, S., Curic, S., Polomac, N., Andreou, C., Eichler, I.C., Eichler, L., Zöllner, C., Gallinat J., Leicht, G., Mulert, C. (2018). Alterations in interhemispheric gamma-band connectivity are related to the emergence of auditory verbal hallucinations in healthy subjects during NMDA-receptor blockade. Neuropsychopharmacology, 43(7), 1608-1615.
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